The Role of Native Collagen in Regenerative Medicine Research
From Structure to Application
Author: Rozhan Vista Mehr Ltd. | Category: Research
Introduction
Regenerative medicine is a rapidly evolving field focused on restoring damaged tissues and organs by stimulating the body’s own healing processes. One of the foundational components in this scientific revolution is collagen—a primary structural protein in the extracellular matrix (ECM) that supports tissue architecture and cell behavior. While various forms of collagen have been studied, native collagen has emerged as a critical biomaterial in regenerative research due to its preserved triple-helix structure and biological functionality.
Why Native Collagen Matters in Regenerative Research
Unlike hydrolyzed collagen, which is fragmented and lacks structural integrity, native collagen retains its full triple-helix structure, mimicking the body's own collagen more closely. This enables interaction with cellular receptors and promotes:
- Fibroblast proliferation
- Keratinocyte migration
- Angiogenesis (formation of new blood vessels)
- Balanced immune response
Advantages of Marine-Sourced Native Collagen
Marine collagen, especially from cold-water fish, offers several advantages over mammalian sources:
- Biocompatibility: Lower risk of disease transmission
- Sustainability: Utilizes fishery by-products
- Stability: High thermal stability
- Low Immunogenicity: Safer for biomedical use
Applications in Tissue Engineering and Wound Healing
Recent studies highlight its use in:
- Wound dressings for chronic wounds
- Scaffolds for cartilage and bone regeneration
- Bio-inks for 3D bioprinting
- Dermal support in cosmetic dermatology
Products like MariXBioHeal™ by Rozhan Vista Mehr Ltd. have shown excellent safety and immune response in evaluations.
Conclusion
Native marine collagen stands out as a safe, functional, and sustainable material in regenerative medicine. Its unique biological properties support its role as a core biomaterial for future medical innovation.
Keywords: Native Collagen, Regenerative Medicine, Marine Biomaterials, Tissue Engineering, Wound Healing