1. Why the Extracellular Matrix Matters

The extracellular matrix (ECM) is more than just a structural scaffold. It regulates how cells grow, migrate, and repair damaged tissue. Made of proteins, enzymes, and growth factors, the ECM provides the biological signals that guide regeneration. When the ECM is disrupted—such as in chronic wounds or burns—the healing process slows down or even stops. Restoring ECM function is therefore a critical step in regenerative medicine.

2. Native Collagen vs. Hydrolyzed Collagen

Collagen is the most abundant protein in the ECM, with Type I collagen playing the leading role in wound healing. However, not all collagen is the same:

– Hydrolyzed collagen is broken down into small peptides. It is widely used in nutrition and cosmetics, but it no longer preserves the original triple-helix structure. Because of this, it cannot fully interact with cells in the same way as natural ECM components.
– Native collagen, in contrast, maintains its triple-helix structure. This allows cells to adhere, proliferate, and deposit new tissue in a way that mimics the natural healing process. For biomedical applications—especially wound care and regenerative medicine—native collagen is therefore the gold standard.

3. The Future of Biomaterial Platforms

Advances in biomaterial platforms now make it possible to extract native collagen in a sustainable and reproducible way, bringing it from lab-scale research to scalable medical applications. Such platforms enable:

– Reliable supply of high-quality native collagen
– Custom formulations for specific clinical and research needs
– Integration into wound dressings, scaffolds, and drug delivery systems
– Collaborative innovation between academia, biotech, and healthcare providers

By connecting research with practical solutions, biomaterial platforms are paving the way for breakthroughs in regenerative medicine.

4. Our Perspective at RVM BioTech

At Rozhan Vista Mehr (RVM BioTech), we are committed to building a native marine collagen platform that bridges scientific discovery with real-world impact. Our mission is to provide safe, effective, and affordable biomaterials for wound healing and tissue regeneration. By preserving the native structure of collagen, we believe we can help unlock the next generation of regenerative therapies.